There had to be a third fight, though, and what a fight it was. With Ali's heavyweight title at stake, the two met in Manila in a fight that will long be seared in boxing history.

PHILADELPHIA (AP) -- Joe Frazier, the former heavyweight champion who handed Muhammad Ali his first defeat yet had to live forever in his shadow, has died after a brief final fight with liver cancer. He was 67.

The family issued a release confirming the boxer's death on Monday night. Frazier, who took on Ali in three momentous fights in the 1970s - including the epic "Thrilla in Manilla" - had been under home hospice care after being diagnosed just weeks ago with the cancer that took his life, a family friend said. Until then, Frazier had been doing regular autograph appearances, including one in Las Vegas in September.

Smokin' Joe was a small yet ferocious fighter who smothered his opponents with punches, including a devastating left hook he used to end many of his fights early. It was the left hook that dropped Ali in the 15th round at Madison Square Garden in 1971 to seal a win in the so-called "Fight of the Century."

Frazier was small for a heavyweight, weighing just 205 pounds when he won the title by stopping Jimmy Ellis in the fifth round of their 1970 fight at Madison Square Garden. But he fought every minute of every round going forward behind a vicious left hook, and there were few fighters who could withstand his constant pressure.

His reign as heavyweight champion lasted only four fights – including the win over Ali – before he ran into an even more fearsome slugger than himself. George Foreman responded to Frazier's constant attack by dropping him three times in the first round and three more in the second before their 1973 fight in Jamaica was waved to a close and the world had a new heavyweight champion.

Two fights later, he met Ali in a rematch of their first fight, only this time the outcome was different. Ali won a 12-round decision, and later that year stopped George Foreman in the Rumble in the Jungle in Zaire.

There had to be a third fight, though, and what a fight it was. With Ali's heavyweight title at stake, the two met in Manila in a fight that will long be seared in boxing history.

Frazier went after Ali round after round, landing his left hook with regularity as he made Ali backpedal around the ring. But Ali responded with left jabs and right hands that found their mark again and again. Even the intense heat inside the arena couldn't stop the two as they fought every minute of every round with neither willing to concede the other one second of the round.

"They told me Joe Frazier was through," Ali told Frazier at one point during the fight.

"They lied," Frazier said, before hitting Ali with a left hook.

Finally, though, Frazier simply couldn't see and Futch would not let him go out for the 15th round. Ali won the fight while on his stool, exhausted and contemplating himself whether to go on.

It was one of the greatest fights ever, but it took a toll. Frazier would fight only two more times, getting knocked out in a rematch with Foreman eight months later before coming back in 1981 for an ill advised fight with Jumbo Cummings.